DES‐Type Interactions To Promote Solvent‐Free and Metal‐Free Reactions between Nitrogen‐Containing Heterocycles and Allylic Alcohols

Nitrogen-containing heterocycles are of great interest to organic chemists since they present in a wide array bioactive molecules. The use allylic alcohols carry out the allylation has been described as sustainable alternative for this type functionalization. Among plethora methodologies described, metals, solvents, or hazardous reagents is ubiquitous. protocol work provided solventless and metal-free alternative, being mediated by easy-to-synthesise reusable 1,3-bis(carboxymethyl)imidazolium chloride. resulted compatible with several nitrogen-containing (i.e. indole, pyrazole, triazole, tetrazole, carbazole, indazole, benzotriazole) alcohols, providing allylated-heterocycles up quantitative yield, possible perform reaction preparative scale.Based on various green metrics (atom economy, stoichiometric factor, mass efficiency, materials recovery parameter, E-factor, EcoScale), overall greenness significance methodology established.